- Electron Microscopy
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Immunogen: N-terminal fragment of human ACTH conjugated to KLH
Isotype: IgG1, kappa
Species Reactivity: Human and Rat. Expected to show a broad species reactivity.
Positive Control: Normal pituitary gland or pituitary tumor.
Specificity: This antibody is specific to Synacthen (aa 1-24 of ACTH); this antibody does not react with CLIP (aa 17-39 of ACTH). Anti-ACTH is a useful marker in classification of pituitary tumors and in the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.