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Species: Mouse
Designation: Mouse Monoclonal
Clone: 8G7G3/1
Isotype: IgG1
Species Reactivity: Human. Others not tested.
Positive Control: Adenocarcinoma of the Lung or Thyroid.
Specificity: This antibody reacts with TTF-1 protein found in adenocarcinomas of the lung and tumors originating in the thyroid. TTF-1 positive cells are found in Type II pneumocytes and Clara cells in the lung. In the thyroid, follicular and parafollicular cells are positive. In lung cancers, Adenocarcinomas are usually positive, while Squamous Cell Carcinomas and Large Cell Carcinomas are rarely positive. In addition, Small-Cell Carcinomas (of any primary site) are usually positive.