Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia.
Epidermal LCs possess strong immunostimulatory capacity and play a central role in the initiation and regulation of immune responses.
Langerin (CD207) is a Ca2+-dependent, C-type lectin domaincontaining, type II transmembrane protein that induces epidermal LCs to differentiate into Birkbeck granules (BG).
BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T-cells. Human spleen, lymph node, thymus, liver, lung and heart express langerin protein.
1 ml
| Clone | 12D6 |
| Application | IHC |
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