This antibody reacts with a 70 kD protein known as Ku (p70).The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86). Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp.
1 ml
| Clone | H-6 |
| Isotype | IgG1 |
| Application | IHC |
| Host | Mouse |
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