CD105 (endoglin) is a disulfide-linked homodimeric cell membrane glycoprotein. It was initially discovered in a human pre-B-cell line.
CD105 functions as a receptor for transforming growth factor (TGF) -?1 and -?3, and modulates TGF-? signaling through interactions with TGF-? receptors 1 and/or 2. CD105 is a proliferation-associated and hypoxia-inducible protein abundantly expressed in angiogenic endothelial cells.
Tumor microvessel density assessed by CD105 immunohistochemical staining in paraffin-embedded tissue sections correlates significantly with tumor aggressiveness and prognosis in many types solid tumors.
10 ml
| Clone | EP274 |
| Isotype | IgG |
| Application | IHC |
| Host | Rabbit |
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